{"id":10914,"date":"2025-03-05T02:50:38","date_gmt":"2025-03-05T02:50:38","guid":{"rendered":"https:\/\/tenessy.com\/?p=10914"},"modified":"2025-05-16T07:46:10","modified_gmt":"2025-05-16T07:46:10","slug":"comparison-of-hpmc-solubility-in-organic-solvents","status":"publish","type":"post","link":"https:\/\/tenessy.com\/cs\/porovnani-rozpustnosti-hpmc-v-organickych-rozpoustedlech\/","title":{"rendered":"Srovn\u00e1n\u00ed rozpustnosti HPMC v organick\u00fdch rozpou\u0161t\u011bdlech"},"content":{"rendered":"
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"HPMC_Sample\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tHPMC (hydroxypropylmethylcelul\u00f3za)<\/a>\u00a0je polymer hojn\u011b pou\u017e\u00edvan\u00fd ve stavebnictv\u00ed,\u00a0osobn\u00ed p\u00e9\u010de<\/a>, farmaceutick\u00e9m a potravin\u00e1\u0159sk\u00e9m pr\u016fmyslu d\u00edky sv\u00e9 jedine\u010dn\u00e9 rozpustnosti a filmotvorn\u00fdm vlastnostem. Rozpustnost je jednou z hlavn\u00edch vlastnost\u00ed, kter\u00e1 ovliv\u0148uje \u00fa\u010dinnost HPMC v r\u016fzn\u00fdch formulac\u00edch. HPMC je zn\u00e1m\u00fd svou rozpustnost\u00ed ve vod\u011b, av\u0161ak jeho rozpustnost v organick\u00fdch rozpou\u0161t\u011bdlech se zna\u010dn\u011b li\u0161\u00ed.\n\nTento \u010dl\u00e1nek se zab\u00fdv\u00e1 interakc\u00ed HPMC s vodou, ethanolem, acetonem, methanolem, methylenchloridem a dal\u0161\u00edmi organick\u00fdmi rozpou\u0161t\u011bdly a poskytuje p\u0159ehlednou tabulku rozpustnosti HPMC pro va\u0161i informaci.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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I.Pro\u010d je rozpustnost HPMC d\u016fle\u017eit\u00e1?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Funk\u010dnost HPMC z\u00e1vis\u00ed na jeho schopnosti rozpou\u0161t\u011bt se nebo bobtnat v ur\u010dit\u00e9m rozpou\u0161t\u011bdle. Nap\u0159\u00edklad n\u00e1t\u011bry l\u00e9\u010div vy\u017eaduj\u00ed, aby se HPMC rozpou\u0161t\u011bl v rychle se odpa\u0159uj\u00edc\u00ed sm\u011bsi rozpou\u0161t\u011bdel a zanech\u00e1val rovnom\u011brn\u00fd film; HPMC se mus\u00ed rovnom\u011brn\u011b rozpou\u0161t\u011bt ve vod\u011b nebo ve sm\u011bsi ethanolu, aby p\u016fsobil jako stabiliz\u00e1tor nebo emulg\u00e1tor; rozpustnost ve studen\u00e9 vod\u011b zaji\u0161\u0165uje, \u017ee HPMC je rovnom\u011brn\u011b rozpt\u00fdlen v cementu bez aglomerace.<\/p>

Rozpustnost HPMC je ovlivn\u011bna faktory, jako je teplota, substituce polymeru (methoxy a hydroxypropyl) a polarita rozpou\u0161t\u011bdla.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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II.Rozpustnost HPMC ve vod\u011b<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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HPMC je dob\u0159e rozpustn\u00fd ve vod\u011b, zejm\u00e9na ve studen\u00e9 vod\u011b. Po p\u0159id\u00e1n\u00ed do vody HPMC disperguje a bobtn\u00e1, pot\u00e9 se zcela rozpust\u00ed a vytvo\u0159\u00ed \u010dir\u00fd nebo m\u00edrn\u011b zakalen\u00fd roztok. Viskozita roztoku z\u00e1vis\u00ed na molekulov\u00e9 hmotnosti a koncentraci HPMC.<\/p>

HPMC je voln\u011b rozpustn\u00fd ve studen\u00e9 vod\u011b. HPMC ve studen\u00e9 vod\u011b rychle hydratuje a vytv\u00e1\u0159\u00ed visk\u00f3zn\u00ed \u010dir\u00fd roztok. To je ide\u00e1ln\u00ed pro v\u00fdrobu sirup\u016f nebo o\u010dn\u00edch kapek.<\/p>

Roztok tvo\u0159\u00ed p\u0159i vysok\u00fdch teplot\u00e1ch gel a po ochlazen\u00ed se znovu rozpou\u0161t\u00ed. Na rozd\u00edl od jin\u00fdch deriv\u00e1t\u016f celul\u00f3zy je HPMC stabiln\u00ed v \u0161irok\u00e9m rozmez\u00ed pH (3-11).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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<\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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III.Rozpustnost HPMC v organick\u00fdch rozpou\u0161t\u011bdlech<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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P\u0159esto\u017ee rozpustnost HPMC v organick\u00fdch rozpou\u0161t\u011bdlech je ni\u017e\u0161\u00ed ne\u017e ve vod\u011b, sm\u011bsi organick\u00fdch rozpou\u0161t\u011bdel a vody se \u0161iroce pou\u017e\u00edvaj\u00ed.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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1.Rozpustnost HPMC v ethanolu<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Vzhledem k n\u00edzk\u00e9 polarit\u011b ethanolu je HPMC t\u00e9m\u011b\u0159 nerozpustn\u00fd. Sm\u011bsi ethanolu a vody (30% ethanol + 70% voda) v\u0161ak mohou HPMC \u00fa\u010dinn\u011b rozpustit. Voda toti\u017e m\u016f\u017ee p\u016fsobit jako spoluspou\u0161t\u011bdlo.<\/p>

Pou\u017eit\u00ed: Sm\u011bsi etanolu se b\u011b\u017en\u011b pou\u017e\u00edvaj\u00ed v n\u00e1t\u011brech tablet. Nap\u0159\u00edklad roztok ethanolu 20% m\u016f\u017ee urychlit schnut\u00ed a sn\u00ed\u017eit viskozitu filmov\u00fdch povlak\u016f.<\/p>

Omezen\u00ed: Vysok\u00e9 koncentrace etanolu (>80%) mohou zp\u016fsobit vysr\u00e1\u017een\u00ed HPMC.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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2.Rozpustnost HPMC v acetonu<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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HPMC je nerozpustn\u00fd v \u010dist\u00e9m acetonu.<\/p>

Chov\u00e1n\u00ed p\u0159i otoku: Ve sm\u011bsi acetonu a vody (50:50) m\u016f\u017ee HPMC nabobtnat, ale zcela se nerozpust\u00ed. Toho se vyu\u017e\u00edv\u00e1 v procesu mikroenkapsulace.<\/p>

Zvl\u00e1\u0161tn\u00ed pou\u017eit\u00ed: Aceton se n\u011bkdy pou\u017e\u00edv\u00e1 k prom\u00fdv\u00e1n\u00ed v\u00fdrobk\u016f na b\u00e1zi HPMC, aby se odstranily ne\u010distoty bez rozpu\u0161t\u011bn\u00ed polymeru.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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3.Rozpustnost HPMC v methanolu<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Podobn\u011b jako ethanol m\u00e1 HPMC omezenou rozpustnost. Sm\u011bsi methanolu a vody (nap\u0159. methanol 40%) mohou zlep\u0161it rozpustnost, ale jsou m\u00e9n\u011b \u010dast\u00e9 kv\u016fli toxicit\u011b methanolu.<\/p>

Farmaceutick\u00e9 aspekty: Metanol by se nem\u011bl pou\u017e\u00edvat v peror\u00e1ln\u00edch nebo lok\u00e1ln\u00edch p\u0159\u00edpravc\u00edch, ale m\u016f\u017ee se pou\u017e\u00edvat v pr\u016fmyslov\u00e9m prost\u0159ed\u00ed pro lit\u00ed rozpou\u0161t\u011bdel.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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4.Rozpustnost HPMC v dichlormethanu (DCM)<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Dichlormethan (DCM) je chlorovan\u00e9 rozpou\u0161t\u011bdlo, kter\u00e9 nerozpou\u0161t\u00ed HPMC. Nepol\u00e1rn\u00ed povaha a nedostate\u010dn\u00e1 schopnost vod\u00edkov\u00e9 vazby DCM jej \u010din\u00ed nekompatibiln\u00edm s HPMC.<\/p>

Syst\u00e9my s ko-rozpou\u0161t\u011bdly: DCM se \u010dasto kombinuje s metanolem (70:30 DCM-metanol) k rozpou\u0161t\u011bn\u00ed HPMC pro su\u0161en\u00ed rozpra\u0161ov\u00e1n\u00edm nebo v\u00fdrobu mikrosf\u00e9r.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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5.Ostatn\u00ed organick\u00e1 rozpou\u0161t\u011bdla<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Isopropylalkohol: chov\u00e1 se podobn\u011b jako ethanol, ale pro rozpu\u0161t\u011bn\u00ed vy\u017eaduje vy\u0161\u0161\u00ed obsah vody.<\/p>

Etylacet\u00e1t: nerozpustn\u00fd; pou\u017e\u00edv\u00e1 se jako nerozpou\u0161t\u011bdlo p\u0159i synt\u00e9ze nano\u010d\u00e1stic HPMC.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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6.HPMC Graf rozpustnosti<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Rozpou\u0161t\u011bdlo<\/strong><\/p><\/td>

Rozpustnost<\/strong><\/p><\/td>

Pozn\u00e1mky<\/strong><\/p><\/td><\/tr>

Voda<\/p><\/td>

Vysok\u00e1 (studen\u00e1), gely (hork\u00e1)<\/p><\/td>

Prim\u00e1rn\u00ed rozpou\u0161t\u011bdlo pro v\u011bt\u0161inu aplikac\u00ed<\/p><\/td><\/tr>

Ethanol<\/p><\/td>

N\u00edzk\u00e1 (\u010dist\u00e1), st\u0159edn\u00ed (s vodou)<\/p><\/td>

Pou\u017e\u00edv\u00e1 se v n\u00e1t\u011brech s vodn\u00edmi sm\u011bsmi<\/p><\/td><\/tr>

Aceton<\/p><\/td>

Nerozpustn\u00e9<\/p><\/td>

Ve sm\u011bs\u00edch m\u016f\u017ee bobtnat<\/p><\/td><\/tr>

Metanol<\/p><\/td>

N\u00edzk\u00e1 (\u010dist\u00e1), st\u0159edn\u00ed (s vodou)<\/p><\/td>

Omezen\u00e9 pou\u017eit\u00ed z d\u016fvodu toxicity<\/p><\/td><\/tr>

Dichlormethan (DCM)<\/p><\/td>

Nerozpustn\u00e9<\/p><\/td>

Pou\u017e\u00edv\u00e1 se se spolurozpou\u0161t\u011bdly pro tvorbu filmu<\/p><\/td><\/tr><\/tbody><\/table>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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IV.Kl\u00ed\u010dov\u00e9 faktory ovliv\u0148uj\u00edc\u00ed rozpustnost<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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  1. Stupe\u0148 substituce: Vy\u0161\u0161\u00ed obsah methoxy zvy\u0161uje kompatibilitu s organick\u00fdmi rozpou\u0161t\u011bdly.<\/li>
  2. Teplota: Teplota: Zah\u0159\u00edv\u00e1n\u00ed sni\u017euje rozpustnost ve vod\u011b (gelovat\u011bn\u00ed), ale zlep\u0161uje dispergovatelnost v organick\u00fdch sm\u011bs\u00edch.<\/li>
  3. Velikost \u010d\u00e1stic: Jemn\u00e9 pr\u00e1\u0161ky hydratuj\u00ed rychleji ne\u017e hrub\u00e9 \u010d\u00e1stice.<\/li>
  4. P\u0159\u00eddatn\u00e9 l\u00e1tky: Plastifik\u00e1tory zvy\u0161uj\u00ed rozpustnost HPMC v organick\u00fdch rozpou\u0161t\u011bdlech.<\/li>
  5. Polarita rozpou\u0161t\u011bdla: Polarita rozpou\u0161t\u011bdel: voda > metanol > etanol > aceton > dichlormethan.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    V.Shrnut\u00ed<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    HPMC je nejl\u00e9pe rozpustn\u00fd ve vod\u011b, ale pro speci\u00e1ln\u00ed aplikace vy\u017eaduje sm\u011bsi organick\u00fdch rozpou\u0161t\u011bdel (nap\u0159. ethanol-voda). \u010cist\u00e1 organick\u00e1 rozpou\u0161t\u011bdla (nap\u0159. aceton nebo methylenchlorid) HPMC nerozpou\u0161t\u011bj\u00ed, ale lze je pou\u017e\u00edt ve slo\u017een\u00fdch syst\u00e9mech. P\u0159i navrhov\u00e1n\u00ed formulac\u00ed na b\u00e1zi HPMC je d\u016fle\u017eit\u00e9 zv\u00e1\u017eit polaritu rozpou\u0161t\u011bdla, stupe\u0148 n\u00e1hrady a teplotu. Pro pr\u016fmyslov\u00e1 odv\u011btv\u00ed, kter\u00e1 se spol\u00e9haj\u00ed na syst\u00e9my zalo\u017een\u00e9 na rozpou\u0161t\u011bdlech, zaji\u0161\u0165uje v\u00fdb\u011br spr\u00e1vn\u00e9 kombinace rozpou\u0161t\u011bdel optim\u00e1ln\u00ed fungov\u00e1n\u00ed HPMC ve slo\u017een\u00ed.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

    Rozpustnost HPMC se v r\u016fzn\u00fdch rozpou\u0161t\u011bdlech zna\u010dn\u011b li\u0161\u00ed, zejm\u00e9na v organick\u00fdch rozpou\u0161t\u011bdlech. Prohl\u00e9dn\u011bte si pros\u00edm tabulku rozpustnosti HPMC.<\/p>","protected":false},"author":1,"featured_media":9971,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-10914","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry-news"],"yoast_head":"\nComparison of HPMC Solubility in Organic Solvents - HPMC|HEMC|HEC|RDP Manufacturer-TENESSY<\/title>\n<meta name=\"description\" content=\"HPMC solubility varies greatly in different solvents, especially in organic solvents. Please view the HPMC solubility chart.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/tenessy.com\/cs\/porovnani-rozpustnosti-hpmc-v-organickych-rozpoustedlech\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Comparison of HPMC Solubility in Organic Solvents - HPMC|HEMC|HEC|RDP Manufacturer-TENESSY\" \/>\n<meta property=\"og:description\" content=\"HPMC solubility varies greatly in different solvents, especially in organic solvents. 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